Fig. 4

Correlation analysis. A Scatterplot of correlations between single genes showing the correlations between 2 genes. Rs and Ps represent Spearman correlation coefficients and p values, respectively, and Rp and Pp represent Pearson correlation coefficients and p values, respectively. B Correlation chord plots between multiple genes. The colour of the line connecting the genes represents the magnitude of the correlation between the two genes. Red and blue represent positive and negative correlations, respectively. The darker the colour, the stronger the correlation. C Heatmap of gene-immune cell correlation. The red and blue colours in the heatmap represent the normalized correlation results. The darker the red colour is, the stronger the positive correlation, and the darker the blue colour is, the stronger the negative correlation. Missing values are shown in white. The colour shade of the orange triangles in the upper left corner of each box indicates the statistical results for correlation differences, where light to dark orange triangles represent p > 0.05, p < 0.05, p < 0.01, and p < 0.001, respectively. D Gene-pathway correlation heatmap showing the correlation between selected genes and selected pathways. Red and blue in the heatmap represent positive and negative values, respectively, of normalized correlations; the darker the red colour is, the stronger the positive correlation, and the darker the blue colour is, the stronger the negative correlation. Missing values are shown in white. The orange triangles in the upper left corner represent different p values according to the colour shade, where light to dark orange represents p > 0.05, p < 0.05, p < 0.01, and p < 0.001, respectively