Fig. 3

Immune infiltration analysis. A Heatmap of differences in immune infiltration between the disease and healthy groups. The top of the heatmap shows the data grouping (healthy and disease groups). The main body of the heatmap shows the normalized immune infiltration scores in squares with different colour gradients. Darker red indicates more infiltration of that immune cell, and darker blue indicates less infiltration of that immune cell. The significance (p value) and fold change (Log2FoldChange) values for the results of the immune infiltration difference analysis are shown on the right side of the heatmap. The calculation of p values and fold changes was based on the limma package. B Box plots of immune infiltration differences. Yellow and gray represent healthy and diseased groups, respectively. “*” indicates the statistical results for immune cell differences. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. C Scatterplot of the correlations between two immune cells. Rs and Ps represent Spearman's correlation coefficients and p values, respectively. Rp and Pp represent Pearson's correlation coefficients and p values, respectively. D Heatmap of the correlation between multiple immune cells, where the numbers in each grid are the corresponding correlation coefficients. Red represents a positive correlation, and blue represents a negative correlation. The darker the colour, the stronger the correlation