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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy

Fig. 7

TBC1D5 inhibits the progression of ccRCC in vivo. A Subcutaneous implantation mouse models were established using vector or TBC1D5-overexpression cells. B Tumor weight of xenografts were measured and compared between vector and TBC1D5-overexpression group after 45 days. C IHC staining of TBC1D5 and MAP1LC3B was performed in the tumor sections from mouse models that were established using cells transfected with vector and TBC1D5-overexpression lentivirus. Scale bar: 20 μm. D Living fluorescence images of the metastasis model in the TBC1D5 overexpression and control groups. E The specimen and hematoxylin and eosin (HE) staining of liver metastasis of tumor. Scale bar: 50 μm. F Oil red staining of subcutaneous tumors specimen. Scale bar: 50 μm. *P < 0.05

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