Fig. 3

CDH4 promotes tumorigenesis and metastasis of PTC cells in vivo. A Representative image of the enucleated subcutaneous tumors from nude mice (n = 5 per group). B, C Growth curves (B) and final tumor weight (C) of each group were shown. D IHC analysis of CD31 in indicated enucleated subcutaneous tumors and the microvascular density (MVD) value was calculated for each group. E Images of HE staining to lung sections with metastatic sites and the number of lung metastatic nodules in each group were measured. *P < 0.05; **P < 0.01