Fig. 6

Schematic showing the mechanism of action of TfRMAb-TNFR in Aβ plaque reduction. TfRMAb-TNFR increases TREM2-positive microglial clustering around Aβ plaques, which is associated with a reduction in mature Aβ plaque load in the 3xTg-AD mice. No change in tau pathology is observed with TfRMAb-TNFR in this mouse model. Figure was prepared using BioRender.com