Fig. 3

Nanostring GeoMx spatial proteomics comparing hippocampal protein expression in Tg-TfRMAb-TNFR and Tg-Saline 3xTg-AD mice. Differentially regulated proteins related to: Aβ [neprilysin (A) and β-secretase 1 (BACE1) (B)], oligodendrocytes [myelin basic protein (C) and oligodendrocyte transcription factor 2 (Oligo2, D)], microglial-function (secreted phosphoprotein 1 (SPP1, E), P2x purinoceptor 7 (P2RX7, F), cluster of differentiation 163 (CD163, G), cathepsin D (Ctsd, H)), RNA processing (TAR DNA-binding protein 43 (Tdp43, I)), neurodegeneration (phospho-α-synuclein (S129, J), neurogranin (NRGN, K)), and autophagy (Unc-51-like kinase 1 (ULK1, L)). Protein expression was studied in the subiculum (upper and lower), CA2, and DG. The data are shown as Mean ± SEM of n = 5–6 mice per group and were analyzed using the Mann–Whitney U test. Outliers have been detailed in Additional file 1: Table S1. *p < 0.05 and **p < 0.01 for the indicated comparisons