Fig. 2

Nanostring GeoMx spatial proteomics comparing hippocampal protein expression in Aβ plaque-bearing vs. plaque-free regions of the 3xTg-AD mice. Volcano plots show the magnitude of change (Log2fold) on the X-axis versus statistical significance on the Y-axis (-Log10(P value)) for plaque-bearing vs. plaque-free comparisons of differentially expressed proteins in 3xTg-AD mice (A). Blue dots represent upregulation, red dots represent downregulation, and black dots represent no statistical (NS) change. Bar plots show log2 fold-change (FC) in protein expression: upregulation (B) and downregulation (C) in the hippocampus. *p < 0.05. Data from n = 6 mice per group and 4 ROIs per mouse