Table 2 Univariate and multivariate Cox regression analyses with relative risk of OS estimated as hazard ratios with 95% confidence intervals and P values by putative prognostic factors in de dovo DLBCL patients

TIM3/Galectin-9 enrichment

 High vs low

0.257:0.111–0.593

0.275:0.071–1.066

0.018

Age

 > 60 vs ≤ 60

0.4:0.157–1.014

0.372:0.094–1.478

0.16

Gender

 Male vs female

0.884:0.383–2.043

–

–

COO

 Non-GCB vs GCB

0.322:0.096–1.084

–

–

PS

 2–5 vs 0–1

0.397:0.163–0.969

0.351:0.079–1.556

0.168

Stage

 III/IV vs I/II

0.282:0.095–0.834

0.25:0.032–1.972

0.188

IPI

 2–5 vs 0–1

0.267:0.098–0.726

6.974:0.501–97.122

0.148

B symptoms

 Yes vs no

0.592:0.251–1.395

–

–

Primary site

 Nodal vs extranodal

0.917:0.389–2.164

–

–

LDH > 220 IU/L

 Yes vs no

0.256:0.072–0.910

0.146:0.018–1.185

0.044