Fig. 9

The possible regulatory mechanism of TIM3/Galectin-9 pathway in DLBCL. (a, c, d Single cell level, b, e, f histology level). a The TFs activated in different cell clusters of CD8⁺TILs predicted by SCENIC; b the correlation between HAVCR2 and TFs activated in CD8-5 cells detected by RNA sequencing; c functional enrichment analysis of LGASL9-coexpressed genes in macrophage by Hallmark gene set; d interaction network of IFNG-IFNGR1/IFNGR2 pathway among macrophages and other clusters in DLBCL; e the correlation between LGALS9 and IFNG, IFNGR1, and IFNGR2 detected by RNA sequencing; f the correlation between STAT1 and IFNG, IFNGR1, and IFNGR2 detected by RNA sequencing