Fig. 4

The key ligand of TIM3-mediated CD8⁺TILs exhaustion in DLBCL. The correlation among TIM3 and its ligand genes (LGALS9, HMGB1, CEACAM1, PTDSS1, PTDSS2) (a), and the composition of CD8⁺TILs detected by scRNA-seq. Red: CD8-5 cells (terminal exhausted CD8⁺TILs) (b); c correlation between the ligand of TIM3 and CD8A, CD8B, and IC gene expression detected by RNA sequencing