Table 2 CircRNAs regulated by drugs or microorganisms in GC

1

Lidocaine

circ_ANO5

Downregulated

Repressor

Sponge miR-21-5p to upregulate LIFR

[99]

2

Astragaloside IV

circDLST

Upregulated

Enhancer

Sponge miR-489-3p to upregulate EIF4A1

[104]

3

Icariin

hsa_circ_0003159

Downregulated

Repressor

Sponge miR-223-3p to upregulate NLRP3

[105]

4

Sinomenine

circTRPM7

Upregulated

Enhancer

sponge miR-145-5p to upregulate PBX3

[107]

5

Berberine

31 circRNAs

Upregulated (19), Downregulated (12)

–

–

[111]

6

H. pylori

circMAN1A2

Upregulated

Enhancer

Sponge miR-1236-3p to upregulate MTA2

[116]

7

H. pylori

circFNDC3B

Upregulated

Enhancer

Sponge miR-942 to upregulate CD44 and miR-510 to upregulate CDH1

[117]

8

H. pylori

circRNA_15430

Downregulated

Repressor

Sponge miR-382-5p to downregulate ZCCHC14

[118]