Emerging roles of circular RNAs in tumorigenesis, progression, and treatment of gastric cancer

Ma, Qiang; Yang, Feifei; Xiao, Bin; Guo, Xiaolan

doi:10.1186/s12967-024-05001-4

Journal of Translational Medicine

Table 1 CircRNAs involved in treatment resistant of GC

From: Emerging roles of circular RNAs in tumorigenesis, progression, and treatment of gastric cancer

No	CircRNA	Drugs or Others	Expression	Role in drug resistance	Molecular mechanism	Refs.
1	hsa_circ_0081143	Cisplatin	Upregulated	Enhancer	Sponge miR-646 to upregulate CDK6	[65]
2	circDONSON	Cisplatin	Upregulated	Enhancer	Sponge miR-802 to upregulate BMI1	[66]
3	circAKT3	Cisplatin	Upregulated	Enhancer	Sponge miR-198 to upregulate PIK3R1	[67]
4	circPVT1	Cisplatin	Upregulated	Enhancer	Sponge miR-152-3p to upregulate HDGF	[68]
5	circARVCF	Cisplatin	Upregulated	Enhancer	Sponge miR-1205 to upregulate FGFR1	[69]
6	circ-LDLRAD3	Cisplatin	Upregulated	Enhancer	Sponge miR-588 to upregulate SOX5	[70]
7	circ_0017274	Cisplatin	Upregulated	Enhancer	Sponge miR-637 to upregulate CDX2	[71]
8	circUBAP2	Cisplatin	Downregulated	Suppressor	Sponge miR-300 to upregulate KAT6B	[72]
9	circVAPA	Cisplatin	Upregulated	Enhancer	Sponge miR-125b-5p to upregulate STAT3	[73]
10	circCCDC66	Cisplatin	Upregulated	Enhancer	Sponge miR-618 to upregulate BCL2	[74]
11	circFN1	Cisplatin	Upregulated	Enhancer	Sponge miR-182-5p	[75]
12	circ_0000260	Cisplatin	Upregulated	Enhancer	Sponge miR-129-5p to upregulate MMP11	[76]
13	circCUL2	Cisplatin	Downregulated	Suppressor	Sponge miR-142-3p to upregulate ROCK2	[77]
14	circMCTP2	Cisplatin	Downregulated	Suppressor	Sponge miR-99a-5p to upregulate MTMR3	[78]
15	circHIPK3	Cisplatin	Upregulated	Enhancer	Sponge miR-508-3p to upregulate BCL-2	[79]
16	circSOD2	Cisplatin	Upregulated	Enhancer	Sponge miR-1296 to upregulate STAT1	[80]
17	circ-MTO1	Oxaliplatin	Downregulated	Suppressor	-	[81]
18	circLRCH3	Oxaliplatin	Upregulated	Enhancer	Sponge miR-383-5p to upregulate FGF7	[82]
19	hsa_circ_0001546	Oxaliplatin	Downregulated	Suppressor	Sponge miR-421 to upregulate ATM	[83]
20	circ_0032821	Oxaliplatin	Upregulated	Enhancer	Sponge miR-515-5p to upregulate SOX9	[84]
21	hsa_circ_0000144	Oxaliplatin	Upregulated	Enhancer	Sponge miR-502-5p to upregulate ADAM9	[85]
22	circMTHFD2	Pemetrexed	Upregulated	Enhancer	Sponge miR-124 to upregulate MDR-1	[86]
23	circ-PVT1	Pemetrexed	Upregulated	Enhancer	Sponge miR-124-3p/ to upregulate ZEB1	[87]
24	circCPM	5-FU	Upregulated	Enhancer	Sponge miR-21-3p to upregulate PRKAA2	[88]
25	circNRIP1	5-FU	Upregulated	Enhancer	Sponge miR-138-5p to upregulate MDR-1	[89]
26	circPRRX1	radiation	Upregulated	Enhancer	Sponge miR-596 to upregulate NKAP	[90]
27	circDLG1	anti-PD-1	Upregulated	Enhancer	Sponge miR-141-3p to upregulate CXCL12	[91]
28	hsa_circ_0000520	Herceptin	Downregulated	Suppressor	Inhibiting PI3K-Akt signaling pathway	[92]

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ISSN: 1479-5876

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