Fig. 4
From: Emerging roles of circular RNAs in tumorigenesis, progression, and treatment of gastric cancer
CircRNAs regulate alternative splicing and mRNA transcription in GC. A. CircURI1 binds to hnRNPM and regulates alternative splicing of the VEGFA gene to elevate the VEGFAe7IN/VEGFAe7EX ratio, ultimately inhibiting GC metastasis. B. CircMRPS35 interacts with KAT7 and recruits it to the promoter regions of FOXO1 and FOXO3a to activate their transcription, which eventually inhibits the proliferation and metastasis of GC