Fig. 3

CircRNAs work as translational templates to contribute to the proliferation and progression of GC. A. CircCOL6A3_030 encodes a 198-amino-acid peptide that promotes the metastasis of GC through currently unknown mechanisms. B. CircAXIN1 produces a 295-amino-acid peptide that interacts with APC to activate the Wnt/β-catenin pathway, ultimately promoting the proliferation of GC. C. CircGSPT1 gets translated into a 283-amino-acids-long peptide that interacts with the vimentin/beclin1/14-3-3 complex, inhibiting the PI3K/AKT/mTOR signaling pathway and suppressing the proliferation and metastasis of GC. D. Hsa_circ_0004872 (circMAPK1) encodes a 109-amino-acid peptide that interacts with MEK1 to inhibit MAPK1 expression, thereby inhibiting the proliferation and metastasis of GC. E. A 529-amino-acid peptide is translated from circDIDO1, which interacts with PARP1 and decrease PARP1 activity. Moreover, circDIDO1 bind to both RBX1 and PRDX2 to promote the degradation of PRDX2. This process finally inhibits the proliferation and metastasis and promotes the apoptosis of GC. F. Hsa_circ_0069982 (circMTHFD2L) encodes a 248-amino-acid peptide that disrupts the interaction between SET and PP2A, which attenuates the phosphorylation of AKT, ERK, and P65 and thus, inhibits the proliferation and metastasis of GC