Fig. 2
From: Emerging roles of circular RNAs in tumorigenesis, progression, and treatment of gastric cancer
The dual roles of circRNAs in regulating GC tumorigenesis or progression and the role of virus-derived circRNAs in GC progression. A. CircTHBS1 promotes GC proliferation and metastasis by upregulating INHBA by sponging miR-204-5p and interacting with HuR. B. CircEIF4G3 interacts with and enhances the degradation of δ-catenin and upregulating SIK1 through miR-4449 sponging, which ultimately promotes GC proliferation and metastasis by downregulating β-catenin. C. The HIF1α-induced EB virus-derived ebv-circLMP2A interacts with KHSRP protein to enhance the decay of VHL mRNA. This mechanism, along with the enhanced expression of HIF1α, forms a regulated loop that ultimately promotes angiogenesis in GC