Table 4 Univariate and multivariate cox regression analysis of ESCC-PS and clinicopathological characteristics for overall survival in validation cohort
Patient characteristics | Univariate Cox analysis | Multivariate Cox analysis | ||
|---|---|---|---|---|
HR (95%CI) | P value | HR (95% CI) | P value | |
Age | ||||
≤ 60 | 1 | 0.495 | ||
> 60 | 1.309 (0.604–2.838) | |||
Gender | ||||
Male | 1 | 0.906 | ||
Female | 0.947 (0.379–2.365) | |||
Smoking history | ||||
No | 1 | 0.660 | ||
Yes | 1.192 (0.546–2.602) | |||
Drinking history | ||||
No | 1 | 0.214 | ||
Yes | 1.641 (0.751–3.583) | |||
T stage | ||||
T1-T2 | 1 | 0.644 | ||
T3-T4 | 1.328 (0.398–4.434) | |||
N stage | ||||
N0-N1 | 1 | 0.482 | ||
N2-N3 | 0.755 (0.345–1.653) | |||
Stage | ||||
III | 1 | 0.673 | ||
IV | 1.205 (0.507–2.862) | |||
Lung metastasis | ||||
No | 1 | 0.172 | ||
Yes | 1.834 (0.768–4.382) | |||
Bone metastasis | ||||
No | 1 | 0.494 | ||
Yes | 1.666 (0.386–7.198) | |||
Liver metastasis | ||||
No | 1 | 0.460 | ||
Yes | 1.497 (0.513–4.362) | |||
Radiotherapy | ||||
No | 1 | 0.025* | ||
Yes | 0.386 (0.168–0.888) | |||
Chemotherapy | ||||
No | 1 | 0.981 | ||
Yes | 1.011 (0.423–2.16) | |||
PD-L1 | ||||
< 57.5% | 1 | 0.037* | 1 | 0.041* |
≥ 57.5% | 0.214 (0. 050–0.909) | 0.213 (0.048–0.942) | ||
ESCC-PS | ||||
ESCC-PS 1 | 1 | < 0.001* | 1 | < 0.001* |
ESCC-PS 2 | 0.167 (0.056–0.496) | 0.168 (0.055–0.516) | ||
ESCC-PS 3 | 0.040 (0.009–0.171) | 0.034 (0.007–0.160) | ||