Table 3 Univariate and multivariate cox regression analysis of ESCC-PS and clinicopathological characteristics for progression-free survival in validation cohort
Patient characteristics | Univariate Cox analysis | Multivariate Cox analysis | ||
|---|---|---|---|---|
HR (95%CI) | P value | HR (95%CI) | P value | |
Age | ||||
≤ 60 | 1 | 0.977 | ||
> 60 | 0.990 (0.507–1.935) | |||
Gender | ||||
Male | 1 | 0.686 | ||
Female | 0.847 (0.378–1.896) | |||
Smoking history | ||||
No | 1 | 0.955 | ||
Yes | 1.021 (0.501–2.081) | |||
Drinking history | ||||
No | 1 | 0.497 | ||
Yes | 1.277 (0.631–2.584) | |||
T stage | ||||
T1-T2 | 1 | 0.895 | ||
T3-T4 | 1.067 (0.411–2.766) | |||
N stage | ||||
N0-N1 | 1 | 0.984 | ||
N2-N3 | 0.993 (0.504–1.959) | |||
Stage | ||||
III | 1 | 0.603 | ||
IV | 1.219 (0.579–2.566) | |||
Lung metastasis | ||||
No | 1 | 0.427 | ||
Yes | 1.412 (0.603–3.311) | |||
Bone metastasis | ||||
No | 1 | 0.996 | ||
Yes | 1.003 (0.235–4.288) | |||
Liver metastasis | ||||
No | 1 | 0.915 | ||
Yes | 1.059 (0.371–3.025) | |||
Radiotherapy | ||||
No | 1 | |||
Yes | 0.543 (0.249–1.185) | 0.125 | ||
Chemotherapy | ||||
No | 1 | 0.771 | ||
Yes | 1.121 (0.519–2.420) | |||
PD-L1 | ||||
< 57.5% | 1 | 0.092* | 1 | 0.009* |
≥ 57.5% | 0.486 (0.210–1.124) | 0.231 (0.077–0.696) | ||
ESCC-PS | ||||
ESCC-PS 1 | 1 | < 0.001* | 1 | < 0.001* |
ESCC-PS 2 | 0.393 (0.172–0.897) | 0.275 (0.108–0.700) | ||
ESCC-PS 3 | 0.055 (0.018–0.173) | 0.029 (0.008–0.111) | ||