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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer

Fig. 1

The Prognostic Value of Methylation on cg09897064 in ZBP1 in Lung Adenocarcinoma. The TCGA database was used to extract methylation and RNA expression data, as well as prognostic information of lung adenocarcinoma patients. A. Screening of prognostic-related methylation-driven immune genes: 6 overlapping genes were identified as prognostic-related methylation-driven immune genes among 2504 immune genes, 221 methylation driver genes, and 389 prognostic genes. B. The univariate COX regression analysis unveiled that the total methylation expression of ZBP1 gene has the most significant impact on prognosis,highlighting methylation as a key determinant of immune gene prognostic information. C-F. Among the 4 methylation sites,cg09897064 demonstrated the strongest correlation with ZBP1 mRNA expression

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Journal of Translational Medicine

ISSN: 1479-5876

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