Table 2 MR-identified genes/proteins with MG risk
Study/Dataset | Genes/Proteins | Method | SNP | Beta | SE | P value | FDR | OR (95%CI) | P het | Colocalization |
|---|---|---|---|---|---|---|---|---|---|---|
eQTLGen | CDC42BPB | IVW | rs10143668 rs11627044 rs12435483 rs192018318 rs2403110 rs75817380 rs77630549 rs8015723 | 0.527 | 0.112 | 2.35 × 10–6 | 0.006 | 1.694 (1.361–2.108) | 0.648 | 0.926 |
eQTLGen | TNFSF12 | IVW | rs10468481 rs11078677 rs12449427 rs1641548 rs2292067 rs60370790 rs62059711 rs72842805 rs78378222 | 0.36 | 0.085 | 2.12 × 10–5 | 0.026 | 1.433 (1.214–1.691) | 0.468 | 0.305 |
eQTLGen | CD226 | IVW | rs17082031 rs1790974 rs3744856 | − 0.428 | 0.107 | 6.21 × 10–5 | 0.039 | 0.652 (0.528–0.804) | 0.649 | 0.815 |
eQTLGen | PRSS36 | Wald ratio | rs78924645 | 1.159 | 0.29 | 6.40 × 10–5 | 0.039 | 3.186 (1.805–5.624) | NA | 0.856 |
ARIC study | PRSS8 | Wald ratio | rs1060506 | 1.447 | 0.319 | 5.69 × 10–6 | 0.004 | 4.252 (2.275–7.945) | NA | 0.982 |
ARIC study | CPN2 | Wald ratio | rs11711157 | − 0.2 | 0.053 | 1.44 × 10–4 | 0.034 | 0.819 (0.739–0.908) | NA | 0.926 |
ARIC study | CTSH | Wald ratio | rs2289702 | 0.197 | 0.052 | 1.44 × 10–4 | 0.034 | 1.218 (1.101–1.348) | NA | 0.894 |
INTEVAL study | CTSH | Wald ratio | rs34593439 | 0.229 | 0.057 | 5.49 × 10–5 | 0.014 | 1.257 (1.125–1.405) | NA | 0.894 |