Fig. 2

Miami plot with circles representing the MR results for gene/protein on MG. FDR, P value (FDR adjust); Black dashed line indicates the threshold for significance (FDR < 0.05) threshold. The x axis is the chromosome and gene start position of each MR finding in the cis region. The y axis represents the − log₁₀ FDR of the MR findings. MR findings with positive effects (increased level of gene expression/protein associated with increasing the MG risk) are represented by filled circles on the top half of the plot; Conversely, MR findings suggesting a negative effect, implying a reduced level of gene expression or protein linked to an elevated risk of MG, are illustrated in the lower half of the plot