Table 3 Mutations and changes in blood samples for the 2nd and 3rd measurements
Variable | Category | Repeatedly measured |
|---|---|---|
2nd measurement | ||
 KRAS mutation in blood | Yes | 15 (48.4) |
 KRAS mutation abundance in blood (%)a |  | 1.1 (0.5–6.5) |
 KRAS mutation abundance in blood ≥ 5.0% | Yes | 6 (19.4) |
 Elevated KRAS mutation abundance in bloodb | Yes | 3 (9.7) |
 Change of KRAS mutation abundance in blood (%)b |  | − 1.7 (− 11.9 to − 0.3) |
 Change of KRAS mutation abundance in bloodb ≤ − 2.0% | Yes | 11 (35.5) |
 TP53 mutation in blood | Yes | 13 (41.9) |
 TP53 mutation abundance in blood (%)a |  | 1.2 (0.4–4.2) |
 TP53 mutation abundance in blood ≥ 5.0% | Yes | 3 (9.7) |
 Elevated TP53mutation abundance in bloodb | Yes | 2 (6.5) |
 Change of TP53mutation abundance in blood (%)b |  | − 1.9 (− 6.0 to − 0.1) |
 Change of TP53mutation abundance in bloodb ≤ − 2.0% | Yes | 9 (29.0) |
 CDKN2A mutation in blood | Yes | 4 (12.9) |
 CDKN2A mutation abundance in blood (%)a |  | 1.5 (0.6–5.9) |
 CDKN2A mutation abundance in blood ≥ 5.0% | Yes | 1 (3.2) |
 Elevated CDKN2A mutation abundance in bloodb | Yes | 1 (3.2) |
 Change of CDKN2A mutation abundance in blood (%)b |  | − 1.1 (− 5.7 to 0.0) |
 Change of CDKN2A mutation abundance in bloodb ≤ − 2.0% | Yes | 2 (6.5) |
3rd measurement | ||
 KRAS mutation in blood | Yes | 12 (38.7) |
 KRAS mutation abundance in blood (%)a |  | 3.7 (1.9–10.6) |
 KRAS mutation abundance in blood ≥ 5.0% | Yes | 5 (16.1) |
 Elevated KRAS mutation abundance in bloodb | Yes | 1 (3.2) |
 Change of KRAS mutation abundance in blood (%)b |  | − 1.7 (− 6.6 to − 0.8) |
 Change of KRAS mutation abundance in bloodb ≤ − 2.0% | Yes | 9 (29.0) |
 TP53 mutation in blood | Yes | 9 (29.0) |
 TP53mutation abundance in blood (%)a |  | 3.1 (1.5–3.6) |
 TP53mutation abundance in blood ≥ 5.0% | Yes | 2 (6.5) |
 Elevated TP53mutation abundance in bloodb | Yes | 2 (6.5) |
 Change of TP53mutation abundance in blood (%)b |  | − 1.9 (− 4.7 to − 0.3) |
 Change of TP53mutation abundance in bloodb ≤ − 2.0% | Yes | 8 (25.8) |
 CDKN2A mutation in blood | Yes | 3 (9.7) |
 CDKN2A mutation abundance in blood (%)a |  | 4.0 (3.1–4.0) |
 CDKN2A mutation abundance in blood ≥ 5.0% | Yes | 0 (0.0) |
 Elevated CDKN2A mutation abundance in bloodb | Yes | 1 (3.2) |
 Change of CDKN2A mutation abundance in blood (%)b |  | − 1.2 (− 3.5 to 0.0) |
 Change of CDKN2A mutation abundance in bloodb ≤ − 2.0% | Yes | 2 (6.5) |