Fig. 1

Metagenomics sequencing of the stool sample and exome and transcriptome sequencing of mucosa tissue in colorectal cancer. We collected stool specimens and matched tumor and normal mucosa tissue from 41 colorectal cancer patients. The former samples were metagenomically shotgun sequenced to yield taxonomic and functional profiles; the latter were processed using exome and transcriptome sequencing technology respectively. Features of the microbiome were correlated with clinic elements somatic mutations, and differentially expressed genes, respectively