Fig. 4

MRM quantification and logistic regression classification of CRC and healthy subjects. A ROC curves of a seven-protein logistic regression classifier (LRG1, C9, IGFBP2, CDNP1, ITIH3, SERPINA1, and ORM1) for distinguishing CRC and healthy subjects in the training and testing datasets. B ROC curve showing the performance of the seven-protein classifier in distinguishing CRC and healthy subjects in an independent validation cohort. C ROC curve showing the performance of the seven-protein classifier in distinguishing CRC and healthy subjects in a blinded validation cohort. D–F Confusion matrix showing the classification accuracy in the training (D), independent validation E, and blinded validation F cohorts