Fig. 9
Graphic model of ZSWIM4 inhibition enhancing the chemosensitivity of EOC cells Epithelial ovarian cancer (EOC) cells survive in the presence of carboplatin by inducing ZSWIM4 expression via FOXK1-mediated transcription. Elevated ZSWIM4 levels upregulate the glycine biosynthesis-associated rate-limiting enzymes represented by SHMT2 and PHGDH, leading to increased intracellular glycine content and decreased levels of reactive oxygen species, further reducing the sensitivity of EOC cells to chemotherapy. IPN60090, a ZSWIM4-targeting inhibitor, enhances the chemosensitivity of EOC cells.