Fig. 8

Patient-derived organoid (PDO) models with ZSWIM4 expression are sensitive to combined therapy. A Immunohistochemical analysis of ZSWIM4 protein expression in EOC tissues from two patients. B, C PDOs were treated with vehicle, CBP (100 μM) combined with PTX (10 nM), IPN60090 (50 μM), or CBP combined with PTX plus IPN60090, and the cell viability was measured on days four and seven using an ATP detection kit. PDO #1 B; PDO#2 C. Typical images (left) and statistical data (mean ± SD) (right). Veh, vehicle. IPN, IPN60090