Fig. 7
ZSWIM4 inhibitor enhances chemotherapy sensitivity in CBP-resistant SKOV3 cells. A Drug sensitivity of CBP in parental SKOV3 and SKOV3/CBP cells. B The protein expression of FOXK1 in parental SKOV3 and SKOV3/CBP cells. C Immunofluorescence detection of ZSWIM4 protein expression in parental SKOV3 and SKOV3/CBP cells. D ZSWIM4 gene promoter-luciferase reporter activity in parental SKOV3 and SKOV3/CBP cells. E IC50 curves of SKOV3/CBP cells with a gradient concentration of CBP with or without IPN60090 (50 μM) treatment for 72 h. (F–I) SKOV3/CBP cells treated with vehicle, CBP (200 μM), IPN60090 (50 μM), and CBP (200 μM) combined with IPN60090 (50 μM) for 72 h. ROS levels F, and statistical data (mean ± SD) G. Flow cytometry analysis of cell apoptosis rate (mean ± SD) H. Cleaved caspase-3 protein abundance I