Fig. 2

Elevated ZSWIM4 resists chemotherapy in epithelial ovarian cancer (EOC) cells. A ZSWIM4 protein expression levels in the vector control and ZSWIM4-overexpressing IOSE-80 and ES-2 cells. B IC₅₀ curves for vector control and ZSWIM4-overexpressing IOSE-80 and ES-2 cells following incubation with a gradient concentration CBP for 72 h. C Immunofluorescence detection of ZSWIM4 protein expression in OVCAR8 and SKOV3 cells after CBP (75 μM) treatment for 48 or 72 h. D ZSWIM4 protein expression in the vector control and ZSWIM4-overexpressing OVCAR8 and SKOV3 cells. E IC₅₀ curves for vector control and ZSWIM4-overexpressing OVCAR8 and SKOV3 cells following incubation with CBP for 72 h. F Statistical data (mean ± SD) of the apoptosis rate in ZSWIM4-overexpressing and vector control OVCAR8 and SKOV3 cells treated with the vehicle control or CBP (50 μM) treatment for 72 h. G Cleaved caspase-3 protein levels in ZSWIM4-overexpressing OVCAR8 and SKOV3 cells treated with CBP (50 μM) for 72 h detected via western blotting