Table 3 Positive staining rates of pathological indicators in the control group, aPD-1 group, and combination group (mean ± standard deviation)

37.6 ± 1.3

39.9 ± 1.7

42.1 ± 1.4

41.6 ± 1.3

43.3 ± 1.3

7.328

0.005

19.2 ± 2.2

18.7 ± 2.7

20.2 ± 2.5

24.4 ± 3.3

24.2 ± 2.9

3.002

0.072

35.0 ± 1.7

36.6 ± 1.5

31.9 ± 1.9

30.3 ± 2.3

30.9 ± 2.5

5.673

0.012

20.3 ± 2.2

19.8 ± 1.7

15.8 ± 1.5

16.3 ± 1.3

14.1 ± 1.4

7.796

0.004

57.8 ± 3.7

54.2 ± 2.6

49.3 ± 2.0

53.9 ± 5.2

45.6 ± 0.8

6.422

0.008

39.5 ± 1.2

40.3 ± 0.9

38.4 ± 0.9

38.7 ± 1.1

38.5 ± 2.0

1.323

0.327

20.5 ± 1.2

21.0 ± 1.4

18.6 ± 1.2

16.8 ± 0.9

12.7 ± 1.7

20.286

 < 0.001

38.4 ± 1.3

37.0 ± 0.3

35.1 ± 1.6

34.4 ± 1.4

31.8 ± 1.7

10.910

0.001

18.6 ± 3.1

24.8 ± 2.8

30.7 ± 3.1

42.4 ± 3.2

47.9 ± 4.7

37.609

 < 0.001

35.5 ± 2.5

44.8 ± 2.2

42.4 ± 2.5

32.6 ± 2.5

28.2 ± 4.4

16.535

 < 0.001

20.6 ± 1.2

25.4 ± 1.8

30.4 ± 2.1

18.7 ± 0.8

15.8 ± 1.7

39.514

 < 0.001

58.5 ± 7.2

56.6 ± 2.5

71.6 ± 0.7

57.7 ± 6.3

57.0 ± 10.8

2.823

0.083

40.5 ± 1.0

42.8 ± 1.0

39.8 ± 1.6

36.8 ± 0.9

36.4 ± 1.1

16.321

 < 0.001

20.7 ± 0.9

22.5 ± 0.7

23.2 ± 0.3

22.8 ± 0.4

17.9 ± 1.1

27.720

 < 0.001

38.3 ± 1.4

35.6 ± 1.1

34.0 ± 1.5

31.2 ± 1.3

27.7 ± 1.3

28.409

 < 0.001

19.0 ± 4.3

25.3 ± 4.1

37.0 ± 3.8

52.3 ± 2.9

58.6 ± 2.7

66.660

 < 0.001

33.8 ± 1.9

42.7 ± 2.0

45.6 ± 2.4

37.1 ± 1.9

33.2 ± 2.2

20.695

 < 0.001

17.6 ± 0.8

30.5 ± 2.6

32.5 ± 1.7

25.1 ± 2.3

18.5 ± 3.0

28.110

 < 0.001

52.2 ± 2.5

71.4 ± 3.9

71.5 ± 7.4

67.4 ± 3.3

55.5 ± 7.0

9.245

0.002

40.4 ± 1.3

44.6 ± 0.9

42.6 ± 1.0

36.6 ± 1.4

37.3 ± 0.7

30.085

 < 0.001

20.6 ± 0.7

24.2 ± 0.9

26.0 ± 0.7

25.3 ± 0.9

23.6 ± 1.0

18.188

 < 0.001