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Table 2 The IVIM-DWI and BOLD-MRI quantitative parameters of the control group, anti-PD-1 group, and combination group in different time points (mean ± standard deviation)

From: Magnetic resonance imaging-based approaches for detecting the efficacy of combining therapy following VEGFR-2 and PD-1 blockade in a colon cancer model

 

Base

3d

6d

9d

12d

F

P

Control

 D (10−3 mm/sec)

0.483 ± 0.008

0.487 ± 0.010

0.472 ± 0.009

0.476 ± 0.007

0.472 ± 0.006

4.251

0.009

 D*(10−3 mm/sec)

3.690 ± 0.051

3.730 ± 0.037

3.700 ± 0.085

3.660 ± 0.080

3.610 ± 0.091

2.246

0.093

 f (%)

15.320 ± 0.331

15.220 ± 0.387

15.220 ± 0.449

15.330 ± 0.683

15.250 ± 0.489

0.079

0.988

 R2* (S−1)

56.221 ± 1.116

55.400 ± 2.074

53.051 ± 1.218

52.891 ± 1.815

53.459 ± 0.723

6.296

0.001

aPD-1

 D (10−3 mm/sec)

0.477 ± 0.011

0.501 ± 0.013

0.518 ± 0.015

0.528 ± 0.007

0.534 ± 0.009

24.876

 < 0.001

 D* (10−3 mm/sec)

3.670 ± 0.072

3.760 ± 0.079

3.810 ± 0.095

3.760 ± 0.086

3.730 ± 0.111

2.010

0.124

 f (%)

15.180 ± 0.624

15.350 ± 0.579

16.130 ± 0.418

15.920 ± 0.791

15.720 ± 0.564

2.509

0.067

 R2* (S−1)

56.589 ± 2.060

51.978 ± 1.317

49.616 ± 1.045

49.914 ± 1.447

52.146 ± 1.065

22.644

 < 0.001

Combination

 D (10−3 mm/sec)

0.478 ± 0.006

0.506 ± 0.045

0.521 ± 0.013

0.558 ± 0.023

0.580 ± 0.009

17.534

 < 0.001

 D* (10−3 mm/sec)

3.640 ± 0.092

3.850 ± 0.088

3.950 ± 0.090

3.890 ± 0.076

3.690 ± 0.075

15.090

 < 0.001

 f (%)

15.170 ± 0.393

16.130 ± 0.568

17.370 ± 0.668

16.580 ± 0.778

16.020 ± 0.655

9.951

 < 0.001

 R2* (S−1)

56.309 ± 1.368

51.831 ± 0.599

41.436 ± 1.857

49.099 ± 1.139

51.773 ± 1.108

110.054

 < 0.001

  1. One-way ANOVA test was used to generate the P-value. The P values in bold indicate statistically significant (P<0.05)
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Journal of Translational Medicine

ISSN: 1479-5876

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