Magnetic resonance imaging-based approaches for detecting the efficacy of combining therapy following VEGFR-2 and PD-1 blockade in a colon cancer model

Table 1 The tumor volumes at each time point in each group (mean ± standard deviation, mm³)

	Control	aPD-1	Combination	F	P	P^a
	Control	aPD-1	Combination	F	P	Control vs aPD-1	Control vs combination	aPD-1 vs combination
Base	185.800 ± 20.093	183.650 ± 17.526	189.000 ± 21.387	0.112	0.895	NS	NS	NS
3d	344.467 ± 48.244	315.767 ± 33.637	303.867 ± 65.036	1.020	0.384	NS	NS	NS
6d	642.533 ± 87.318	468.350 ± 89.289	318.733 ± 34.216	28.192	< 0.001	0.001	< 0.001	0.003
9d	985.317 ± 77.350	472.850 ± 75.600	378.223 ± 45.691	139.303	< 0.001	< 0.001	< 0.001	0.029
12d	1347.000 ± 69.155	583.100 ± 86.481	404.650 ± 32.692	338.346	< 0.001	< 0.001	< 0.001	< 0.001

The tumor volumes among different time points in each group were compared using a one-way ANOVA test. If the test was significant (P < 0.05), LSD test was performed to test further significant differences between variables, and a P^a value < 0.05 was considered statistically significant
NS nonsignificant

ISSN: 1479-5876