Fig. 4

Dynamic changes of IVIM-DWI and BOLD-MRI parameters at different time point in the control group, anti-PD-1 group, and combination group. The data points presented as mean and standard deviation. Comparisons among the three groups at each time point using a one-way ANOVA test (*P < 0.05, **P < 0.01, ***P < 0.001). If the test was significant, LSD test was performed to test further significant differences between variables. We marked the time points where significant differences existed between the combination therapy group and anti-PD-1 therapy group (P < 0.05, P < 0.01, P < 0.001)