Fig. 8

Overexpression of SP1 promotes RBBP7 proliferation and glycolysis in HCC in vivo. A. Tumors formed in nude mice injected with Vector + shNC, Vector + shRBBP7-2, oeSP1 + shNC, and oeSP1 + shRBBP7-2 cells. (n = 6). B. Volume of tumors formed in different groups. C. The weight of the final tumors formed in the various groups. The expression of RBBP7 (D), SP1 (E), LDHA (Supplemental Fig.2), PFKM (Supplemental Fig.3), and PKM2 (Supplemental Fig.4) in the different groups was measured by immunofluorescence staining. (100x). F. Schematic representation of RBBP7 function and mechanisms of action in HCC