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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling

Fig. 5

RBBP7 promotes HCC through the PI3K/AKT signaling. Compared with Hep3B-NC + Vehicle group *, P < 0.05, **, P < 0.01, ***, P < 0.001. ****, P < 0.0001. Compared with Hep3B-OE + Vehicle group #, P < 0.05, ##, P < 0.01, ###, P < 0.001. ####, P < 0.0001. A. GSEA was performed to identify the RBBP7 signaling pathway. B. PI3K, p-PI3K, AKT, and p-AKT expression in RBBP7 overexpression and vector control cells measured by western blotting. C. PI3K, p-PI3K, AKT, and p-AKT expression in RBBP7 knockdown and vector control cells measured by western blotting. D. CCK-8 assay was employed to examine the growth of RBBP7-overexpressing cells in the PI3K signaling pathway rescue experiment. E, F. In the PI3K signaling pathway rescue experiment, a colony formation assay was used to assess the growth of RBBP7-overexpressing cells. G. Lactic acid concentration in RBBP7-overexpressing cells during the PI3K pathway rescue experiment. H. Glucose uptake capacity in RBBP7-overexpressing cells during PI3K pathway rescue experiment. I. ATP concentration in RBBP7-overexpressing cells during the PI3K pathway rescue experiment. J. NAD+/NADH colorimetric assay in RBBP7-overexpressing cells during PI3K pathway rescue experiment

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Journal of Translational Medicine

ISSN: 1479-5876

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