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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling

Fig. 3

RBBP7 downregulated suppressive HCC cell proliferation and glycolysis in vitro. Compared with shNC group *, P < 0.05, **, P < 0.01, ***, P < 0.001. ****, P < 0.0001. A, B. RBBP7 downregulation was established in PLCPRF5 and was successfully verified by western blotting analysis and RT-qPCR. C. CCK-8 assay was performed to examine cell growth after RBBP7 knockdown. D, E. A colony formation assay was conducted using RBBP7 knockdown cells. F. ATP concentration in RBBP7 knockdown and vector control. G. Lactic acid concentration in RBBP7 knockdown and vector control. H. Glucose uptake capacity of RBBP7 knockdown and vector control. I. NAD+/NADH colorimetric assay of RBBP7 knockdown and vector control. J. Expression of glycolysis-associated proteins (PFKM, PKM2, and LDHA) in RBBP7 knockdown and vector control cells

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Journal of Translational Medicine

ISSN: 1479-5876

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