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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling

Fig. 2

RBBP7 upregulation enhanced HCC proliferation and glycolysis in vitro. Compared with Hep3B-VC group *, P < 0.05, **, P < 0.01, ***, P < 0.001. ****, P < 0.0001. A, B. A stable RBBP7 overexpression model was established in the Hep3B. The upregulated expression of RBBP7 was confirmed through western blotting analysis and RT-qPCR. C. The CCK-8 assay was performed to examine cell growth after RBBP7 overexpression. D, E. A colony formation assay was conducted using Hep3B overexpression cells. F. ATP concentration in RBBP7 overexpression and vector control cells. G. Lactic acid concentration in upregulation of RBBP7 and vector control cells. H. Glucose uptake capacity of upregulation of RBBP7 and vector control cells. I. NAD+/NADH colorimetric assay of upregulation of RBBP7 and vector control cells. J. Glycolysis-associated proteins (PFKM, PKM2, and LDHA) in RBBP7-overexpressing and vector control cells

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Journal of Translational Medicine

ISSN: 1479-5876

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