Fig. 1
From: Hypoxia promotes metastasis by relieving miR-598-3p-restricted glycolysis in gastric cancer
Integrated analysis of key miRNAs involved in hypoxic gastric cancer cells. A Heatmap of differentially expressed miRNAs of miRNA Chip of MKN45 cells cultured in 21% O2 (normoxia) or 1% O2 (hypoxia). (Fold change ≥ 2, p value < 0.01). B Scatter plot showing the upregulated and downregulated miRNAs induced by hypoxia based on miRNA Chip analysis (Fold change ≥ 2, p value < 0.01). C Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the miRNAs identified to be differentially expressed between the normoxia and hypoxia groups (P < 0.05 by Fisher’s exact test). D Real-time PCR analysis of the indicated miRNA levels in SGC-7901 cells cultured in 21%O2 or 1%O2. E Real-time PCR analysis of miR-598-3p levels in SGC-7901 or MKN45 cells treated with the indicated concentrations of CoCl2. F Venn diagram showing prognostic genes derived from online tools of miRpathDB (https://mpd.bioinf.uni-sb.de/) and Targetscan 7.1 (https://www.targetscan.org/vert_71/). G KEGG pathway enrichment analysis of the miRNAs identified to be differentially expressed between the normoxia and hypoxia groups (P < 0.05 by Fisher’s exact test)