Fig. 8

Predictive value of LRG signature for immunotherapy. A Boxplot of TIDE score between the high- and low-risk group. A higher score indicates enhanced probability of immune invasion. B Scatter plot of ESTIMATE indicates a positive relationship between risk score and TIDE score. C Heatmap of Submap analysis of the two groups (Bonferroni-corrected p < 0.05). For Submap analysis, a smaller p-value implied a more similarity of paired expression profile. D–G survival curve (D) and immunotherapy response (E) between high risk and low risk group in IMvigor210 cohort and survival curve of patients at stage I/II (F) and III/IV (G). H, I. survival curve (H) and immunotherapy response (I) between high risk and low risk group in GSE78220 cohort. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001