Fig. 6

Prediction of biological mechanisms associated with LRGs risk. A Oncoprint visualization of the mutation atlas of these essential LRGs across CRC samples from TCGA cohort. B Co-mutation status between these essential LRGs and some commonly mutated genes. C The mutation frequencies of ten prevalent oncogenic pathways in high-risk group. D Identification of GO terms enriched in the high-risk group through GSEA analysis in TCGA. E Ridge plot showing the GO terms enriched in the low-risk group. F Assessment of variations in hallmark pathway activities between high- and low-risk groups based on GSVA scores. G Evaluation of the correlation between the LRG risk score and the activities of hallmark pathway. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001