Fig. 4

Novel LRG signature unveils strong predictive power for CRC prognosis. A Volcano plot illustrating prognostic-associated LRGs identified through univariate Cox proportional hazards analysis. B LASSO regression analysis included 23 prognostic LRGs to identify the most critical model genes. C Coefficients for model genes determined by multiple Cox proportional hazard ratios. Red indicates risk genes, and blue indicates protective genes. D Kaplan–Meier curves of Overall Survival (OS) based on the LRG risk signature in the TCGA dataset, accompanied by a time-dependent ROC curve demonstrating the survival accuracy of the model. E, F Kaplan–Meier curves of OS based on the LRG risk signature in the GEO datasets (GSE39582 and GSE17536), with a time-dependent ROC curve illustrating the survival accuracy of the model