Fig. 4

Comparison of genetic variations and transcriptomic profiles among patient’s tumors and PDX or CPDX generations. For each analysis, tumors at first (P1) and second (P2) generations cluster together with the respective original patient tumors (Pz#). A–D Clustered heatmap of the correlation coefficients for SNVs and gene expression levels, respectively. B–E Hierarchical clustering using Euclidian distance and Ward’s method for SNVs and gene expression levels, respectively. C–F Principal Component Analysis and Scree Plot (bottom right) for SNVs and gene expression levels, respectively