Association of dietary flavonoid intakes with prevalence of chronic respiratory diseases in adults

Table 5 The mediation effects of inflammatory markers on the association of dietary total flavonoid intake levels with the prevalence of chronic respiratory diseases (CRDs) among adults in NHANES 2007–2010 and 2017–2018

Mediators	Indirect effects	Direct effects	Mediated proportion (%)	P value
Mediators	β (95%CI)	β (95%CI)	Mediated proportion (%)	P value
CRP	− 0.0023 (− 0.0034, − 0.0014)	− 0.0156 (− 0.0300, − 0.0026)	12.64%	0.01
WBC	− 0.0010 (− 0.0018, − 0.0003)	− 0.0164 (− 0.0302, − 0.0035)	5.42%	0.02
NEU	− 0.0009 (− 0.0017, − 0.0003)	− 0.0170 (− 0.0312, − 0.0021)	5.01%	0.02
LYM	0.0001 (− 0.0001, 0.0004)	− 0.0179 (− 0.0327, − 0.0034)	0.43%	0.42
MON	− 0.0004 (− 0.0009, 0.0001)	− 0.0173 (− 0.0326, − 0.0031)	1.93%	0.12
RDW	− 0.0015 (− 0.0025, − 0.0008)	− 0.0161 (− 0.0286, − 0.0013)	8.34%	0.03

CI, confidence interval; CRP, C-reactive protein; WBC, white blood cell count; NEU, neutrophil count; LYM, lymphocyte count; MON, monocyte count; RDW, red blood Cell distribution width. Model was adjusted as age (< 40, 40–59, or > 59), sex (male or female), race/ethnicity (Mexican American, Other Hispanic, Non-Hispanic White, Non-Hispanic Black or Other), education level (below high school, high school, or above high school), family poverty income ratio (≤ 1.0, 1.1–3.0, or > 3.0), smoking status (never smoker, former smoker, or current smoker), energy intake levels (in tertiles), metabolic syndrome (yes or no), and supplement use (yes or no)

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