Fig. 7

Cell–cell interaction networks in primary liver tumors and metastatic liver tumors. A Heatmap illustrating the cell–cell interaction patterns in NTs, PTs, and MTs. B Heatmap showing the pair-wise comparison changes of interaction intensities between NTs, PTs, or MTs. C Circle plot showing the interaction intensities of the outgoing interactions of malignant hepatocytes with other cell types in NTs (top) and PTs (bottom), respectively. D Heatmap showing the enriched outgoing ligand–receptor interaction intensities of hepatocytes with other cell types in NTs and PTs, and their fold changes in PTs compared to NTs. E Scatter plots showing the correlations of signature scores between the malignant hepatocytes and the involved ligands, the CD4+ T cells and the involved receptors, the malignant hepatocytes and CD4+ T cells, and the involved ligands and CD4+ T cells in PTs from the TCGA-LIHC cohort (n = 374). F Circle plot showing the interaction intensities of the outgoing interactions of fibroblasts with other cell types in PTs (top) and MTs (bottom), respectively. G Heatmap showing the enriched outgoing ligand–receptor interaction intensities of fibroblasts with other cell types in PTs and MTs, and their fold changes in MTs compared to PTs. H Scatter plots showing the correlations of signature scores between the fibroblasts and the involved ligands, the malignant epithelial cells and the involved receptors, the fibroblasts and malignant epithelial cells, and the involved ligands and malignant epithelial cells in MTs from the MT2020 cohort (n = 198). I Spatial distributions of the fibroblasts, the involved ligands, the malignant epithelial cells and the involved receptors in a metastatic liver tumor (L1) determined by the spatial transcriptomic data (GSE225857)