Fig. 7
Oncogenic properties of USP14 in oral squamous cell carcinoma xenograft mouse models. A–C A total of 2 × 106 HN6 cells stably transfecting with either shCtrl, shUSP14-1#, or shUSP14-1# + PFKL were subcutaneously injected into nude mice to establish an OSCC xenograft mouse model. After 3 weeks, tumors from 15 of the mice were extracted and photographed. Tumor images (A), tumor volume (B) and weight (C) were then assessed. D Expression pattern of Ki-67 was examined by immunohistochemistry analysis in the xenograft tumors of each group. Original magnification, ×100. **P < 0.01, ***P < 0.001