Fig. 2

Research process of this Mendelian randomization study. SNPs: single nucleotide polymorphisms; PBC: primary biliary cholangitis; PSC: primary sclerosing cholangitis; TB-BMD: total body bone mineral density; FN-BMD: femur neck bone mineral density; LS-BMD: lumbar spine bone mineral density; eBMD: heel bone mineral density; ALM: appendicular lean mass; LD: linkage disequilibrium; HCC: hepatocellular carcinoma; FA-BMD: forearm bone mineral density; OA: osteoarthritis; ALL OA: any site osteoarthritis; GWAS: genome-wide association study; MR-PRESSO: MR Pleiotropy RESidual Sum and Outlier; MR: Mendelian randomization; LCV: latent causal variable