Fig. 1
From: Harnessing the potential of HLA-G in cancer therapy: advances, challenges, and prospects
Regulation of HLA-G expression. The transcriptional activity of HLA-G is modulated by epigenetic alterations and several transcription factors in response to environmental and drug stimuli. A number of miRNAs can directly target the 3'UTR of HLA-G mRNA and impede HLA-G translation. HLA-G is also subjected to diverse post-translational modifications, including ubiquitination, nitration, and glycosylation. Moreover, various hormones, cytokines, and chemotherapy drugs can enhance HLA-G expression via direct binding with HLA-G gene or activation of downstream signaling pathways. Ac acetylation, Me methylation, Ub ubiquitination, Glc glycosylation, NO nitration