Fig. 2
From: Systematic integration of molecular and clinical approaches in HCV-induced hepatocellular carcinoma
MiRNA-mRNA functional analysis and hepatotoxicity. A A Venn diagram showing miRNA‒mRNA targets: L-HCV miRNA (hsa-miR-215-5p, hsamiR-10b-5p, hsa-let-7a-5p) targets from miRDB (n = 1488), TargetScan (n = 1648) and miRPathDB (n = 11,110) and their intersecting miRNA‒mRNA targets (n = 901). B A Venn diagram showing genes in the HCV-HCC cohort (n = 1946) and miRNA‒mRNA targets (n = 901) with their intersecting genes (n = 107). C Canonical pathways and associated network functions of the combined overlapping (n = 107) genes in the HCV-HCC cohort. Gene Ontology (GO) enrichment analysis: D biological process, E molecular function and F cellular component. G Ingenuity Pathways Analysis (IPA) hepatotoxicity of 107 miRNAs‒mRNA predicted targets. Statistical significance value P < 0.05