A novel sub-regional radiomics model to predict immunotherapy response in non-small cell lung carcinoma

Table 3 Univariate and multivariate analyses for the response in the training cohort

Variable	Univariate analysis		Multivariate analysis
Variable	OR (95% CI)	P-value	OR (95% CI)	P-value
Sex (female vs. male)	0.87 (0.36–2.05)	0.762	–	–
Age (years) (≤ 60 vs. > 60)	0.47 (0.12–1.40)	0.208	–	–
Smoking status (smoker vs. non-smoker)	0.49 (0.10–1.64)	0.293	–	–
TMB score (high vs. low)	0.42 (0.17–1.00)	0.049*	0.32 (0.07–1.14)	0.087
PD-L1 score (high vs. low)	0.15 (0.05–0.37)	< 0.001*	0.09 (0.02–0.33)	< 0.001*
SRRM (high vs. low)	27.18 (9.16–95.87)	< 0.001*	37.32 (10.00–196.64)	< 0.001*

OR odds ratio, CI confidence interval, TMB tumor mutational burden, PD-L1 programmed death-ligand 1, SRRM sub-regional radiomics model
*P-value < 0.05

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