Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis

Table 2 The predictive value of relevant indexes of IPN patients on admission in training and validation cohort

Index	AUC	Sensitivity (%)	Specificity (%)
Training cohort
APACHE II	0.926	96.2	81.9
nCD64 index (%)	0.859	80.8	87.5
SOFA	0.769	69.2	73.3
PCT (μg/L)	0.763	76.9	68.8
IG%	0.680	50.0	84.7
CRP (mg/L)	0.583	76.9	46.6
Neutrophils	0.581	776.9	43.2
WBC	0.549	73.1	45.5
APACHE II + nCD64 index	0.934	100.0	79.6
SOFA + nCD64 index	0.904	88.5	80.1
PCT + nCD64 index	0.885	80.8	86.4
Neutrophils + nCD64 index	0.866	80.8	84.7
WBC + nCD64 index	0.860	80.8	87.5
IG% + nCD64 index	0.859	80.8	87.5
CRP + nCD64 index	0.856	80.8	89.2
Validation cohort
APACHE II	0.924	83.3	80.6
nCD64 index (%)	0.919	100.0	76.6
SOFA	0.841	66.7	73.4
IG%	0.785	50.0	84.0
PCT (μg/L)	0.719	83.3	52.1
CRP (mg/L)	0.674	83.3	27.7
Neutrophils	0.543	66.7	61.7
WBC	0.523	50.0	75.5
APACHE II + nCD64 index	0.927	100.0	80.9
SOFA + nCD64 index	0.926	100.0	75.5
Neutrophils + nCD64 index	0.924	100.0	77.7
WBC + nCD64 index	0.922	100.0	77.7
IG% + nCD64 index	0.922	100.0	78.7
CRP + nCD64 index	0.920	100.0	76.6
PCT + nCD64 index	0.918	100.0	77.7
SOFA + nCD64 index	0.926	100.0	75.5

The collection time point for CRP, WBC, neutrophils, PCT, IG%, and nCD64 index in the Additional file 1: Table S2 was the first day of patient admission. Regarding the joint analysis of indicators, firstly, a binary logistic regression analysis was conducted to combine these two indicators, and a new composite index was created. Subsequently, a related ROC curve analysis was performed
nCD64 index neutrophil CD64 index, APACHE II acute physiological and chronic health score, CRP C reactive protein, PCT procalcitonin, IG immature granulocyte, SOFA sequential organ failure assessment, IPN infected pancreatic necrosis, WBC white blood cells

ISSN: 1479-5876