Fig. 1

Prognostic analysis of the six-gene signature model in the TCGA-BRCA cohort. a Tuning parameter selection by tenfold cross-validation in the LASSO model and trajectory changes of each independent variable. The partial likelihood deviance was plotted against log (Lambda/λ), and λ was the tuning parameter. The Y-axis shows LASSO coefficients and the X-axis is − log (lambda); b Univariate Cox regression analysis result of six genes; c DCA analysis; d The distributions of overall survival status, overall survival and risk score in the TCGA-BRCA cohort; Hierarchical clustering of six core genes between low- and high-risk groups. Red, up-regulated; Blue, down-regulated; e Kaplan–Meier survival curve based on the six-gene signature; f ROC curve of the 6-gene signature for 1-year, 3-year and 5-year survival in the training set