Skip to main content
Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Fig. 7

HMGCS1 reversed the oncogenic effects of ACSS2 and regulated lipid metabolism. A–C Overexpression of HMGCS1 reversed the inhibitory effect of ACSS2 knocked down on pNENs cell migration and invasion. D Overexpression of HMGCS1 reversed the inhibitory effect of ACSS2 knocked down on PI3K/AKT/mTOR pathway. E Overexpression of HMGCS1 in ACSS2 knocked down pNENs cells increased the lipid droplets. F Overexpression of HMGCS1 in ACSS2 knocked down pNENs cells increased the triglyceride. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us